A small molecule, not a peptide, promoted as an "exercise in a pill". All published data is from mice; nothing has been tested in humans.
Endurance exercise switches on a family of genes that build more mitochondria and shift muscle toward burning fat. A group of nuclear receptors called ERRs sit near the top of that programme. SLU-PP-332 activates them directly. In mice this increased running endurance and reduced fat gain on a high-fat diet without the animals exercising. No human has taken it in a published trial.
A synthetic pan-agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ, orphan nuclear receptors that regulate oxidative phosphorylation, mitochondrial biogenesis and fatty acid oxidation in concert with PGC-1α. Rodent administration induces an oxidative gene programme in skeletal muscle, increases exercise capacity, and improves metabolic parameters in diet-induced obesity, with reported effects on heart failure models. Human pharmacokinetics, receptor selectivity consequences and chronic safety are entirely uncharacterised.
Research areas
Community-specified data
Source note: Can bump to 1000mcg -> 1500 -> 2000mcg
Source note: Can bump to 1000mcg -> 1500 -> 2000mcg
Not medical guidance. These third-party figures have not been independently verified, clinically reviewed, or endorsed by DB Peptide. They may be inaccurate or unsafe and should not replace product labelling or advice from a qualified clinician.
Every protocol below is reproduced from a published study or approved labelling, with its source named. These are records of what was studied — not recommendations, and not a suggestion that any of them is appropriate for any person.
| Protocol as reported | Source |
|---|---|
| Intraperitoneal SLU-PP-332 in mice, with endurance and metabolic endpoints measured over days to weeksRodent only. No human dose can be inferred from this. | Billon et al., Journal of Pharmacology and Experimental Therapeutics 2023 |
No human trials of any phase. All data is preclinical.
No, and nothing has shown that it does in a human. In mice it reproduces part of the muscle gene programme that endurance training induces. Exercise also affects cardiovascular, skeletal, cognitive and metabolic systems in ways a single nuclear-receptor agonist does not.
Medical disclaimer
This page is for informational and research purposes only. Nothing here constitutes medical advice. The compounds discussed are research chemicals. Consult a qualified clinician before starting any protocol.
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